A Brief Introduction to SanYang KangTai Medicine

Approval Certificate No. Z20025065

l      Names of the product 

The proprietary name is Sanyang kantai (SYKT)

The official name is Jiangjie Hematinic Mixture.

l      Main Ingredients  

Natural plants, such as Radix Notoginseng, Draconis Sanguis, Angelica, Licorice, and so on.

l      Characteristics  

The herb is a kind of yellow and brown liquid, and is slightly sweet in taste.

l      Actions   

The herb is suitable for:

Reducing the toxicity and side effects from radiotherapy and chemotherapy. Curing Leukopenia and Thrombocytopenia caused by radiotherapy and chemotherapy, thereby improving the quality of living of  patients with cancer undergoing surgery, radiotherapy and chemotherapy.

Curing Anemia resulting from malnutrition, Hemorrhagic Anemia and Thrombocytopenic Purpura.

Improving the patient’s immune functions.

l      Nonclinical Research  

The Cancer Institute of the Chinese Academy of Medical Science and Kunming Medical College jointly used this herb while performing acute toxicity tests, long-term toxicity tests, and other researches on white blood cell regeneration and immunity enhancement. The results are as follows: 

Results of Toxicologic and Pharmacodynamic Studies on Sanyang Kantai

         Results

Indicators

Test results

Testing Organization

Notes

Regeneration functions of white blood cells

p<0.01

Chinese Academy of Medical Science

Evident,

mock of Mitomycin

Regeneration functions of white blood cells

p<0.01

Kunming Medical College

Evident,

mock of Endoxan

Functions of malrophages

p<0.01

Kunming Medical College

Evident

Effects of immunological enhancement

p<0.05

Kunming Medical College

Evident

Comparison of the survival ratio of white rats

p<0.01

The Tumor Institute of the Chinese Academy of Medical Science

SYKT group :56.2%

G-CSF group: 37.5%

Depressing survival experiment on human lung cancer cells lineA-549 in vitro

p<0.01

Shanghai Comman Pharmaceutical Co., Ltd.

There is a stable and certain role on depressing survival of cells lineA-549

Acute toxicity tests

(ICR mouse)

Secure,

no side effects

Kunming Medical College

LD50 M.T.D

Long-term toxicity tests

(S.D white rats)

Secure,

no side effects

Kunming Medical College

Observe for 30 days

 

l        The research of toxicity reduction and survival ratio of white rats   

The chief scientist of molecular biology at the Cancer Institute of the Chinese Academy of Medical Science, Xu Ningzhi, proved through tests that sanyang kantai can reduce the toxicity and side effects of chemotherapeutics, while protecting white and red blood cells and thrombocytes. The white rat survival experiment showed that the survival ratio of the rats in the sanyang kantai group is 56.2%, which is higher than that of the rhG-CSF group (survival ratio of 37.5%). Considering the quality of living of the white rats and their developmental trend, we can conclude that the long-term curative effect of sanyang kantai is more effective (refer to graph):

 

The Survival Graph for the White Rats

 

 

 

 

 

 

 

l        In the following chart, we shall compare the aggregative indicators of the SYKT  group and that of the G-CSF group.

The Comparison Chart of the Aggregative Indicators of the SYKT Group and the G-CSF Group

Project

 

 

 

 

 

Herb

White blood cells

Red blood cells

Thrombocyte

The effect of sensitivity enhancement

Quality of living

The economic indicators of treatment

Time needed for the herb to begin its curative effect

Time the curative effects of the herb will last

SYKT

About 5 days

Persistent

Effective

Effective

Evident

Clear

1820 Yuan per month

G-CSF

12-24 hours

Unabiding

Non-

Effective

Non-

effective

Not

evident

Not clear

10800 Yuan per month

l        Notes 

A. The effect of sensitivity enhancement refers to the treatment indicators of the non-small cell lung cancer, which is not sensitive to radiotherapy and chemotherapy.

B. Quality of living: refers to the indicators of living quality of a cancer patient during the time when he receives radiotherapy and chemotherapy.

C. The economic indicators of treatment: refers to a kind of indicators which can evaluate the social value of a herb, and this kind of indicators involves medical insurance premiums covered by the government and the costs of herbs that patients must pay.

l        Clinical Study 

The clinical study of this drug is performed in the Tumor Hospital of the Chinese Academy of Medical Science and the Sino-Japanese Friendship Hospital. The curative effect is appraised according to the tumor appraisal standards of the WHO. The quality of living of patients with cancer is assessed according to QOL, and the general situation of the patients is assessed according to KPS standards. A brief introduction is as follows:

The clinical study of the sensitivity enhancement effect of sanyang kantai to chemotherapy given to middle and advanced stage lung cancer patients    Professor Zhao Hongchang and Doctor Zhang Wei from the Sino-Japanese Friendship Hospital performed the clinical study on the sensitivity enhancement effect of sanyang kantai to chemotherapy given to middle and advanced stage lung cancer patients. The observed results are as follows: There is a general remission rate of: CR+PR=84.48% in the treatment group (observed 116 cases: SYKT+ chemotherapy) while a general remission rate of: CR+PR = 59.26% in the control group (observed 108 cases: G-CSF + chemotherapy). The general remission rate of the treatment group is obviously higher than that of the control group (p<0.01). The curative effect for adenocarcinoma of lung which is not sensitive to chemotherapy is especially good.

We found through treatments that sanyang kantai can reduce the toxicity and side effects caused by chemotherapy. The long-term follow-up results of sanyang kantai towards the reduction of white blood cells resulting from chemotherapy are much better than that of G-CSF. At the same time, sanyang kantai can protect red blood cells and thrombocytes, and can evidently improve the quality of living of cancer patients.(see the clinical report written by Professor Zhao Hongchang and Doctor Zhangwei)

The Clinical Curative Effect Graph for SYKT and G-CSF

 

 

 

 

 

 

 

 

 

A phased progress had been achieved in using sanyang kantai and radiotherapy to treat local advanced stage non-small cell lung cancer. No evidence shows an ideal cure to middle and advanced stage non-small cell lung cancer with modern medical science in the past. However, a the clinical study performed in the Sino-Japanese Friendship Hospital now finds that sanyang kantai is effective in treating non-small cell lung cancer together with chemotherapy. With the permission of the director of National Tumor GCP Center, Sunyan (an academician of the Chinese Academy of Science) and with the Tumor Hospital of the Chinese Academy of Medical Science taking the lead, Peking Union Hospital and other medical organizations jointly conducted "polycentric, random, and double blind trials of treating local late stage non-small cell lung cancer with radiotherapy and sanyang kantai". There isn't another example like this one amongst similar traditional Chinese medicines and patent medicines. Currently, this work has been completed 40%, and the phased achievements show that sanyang kantai group is superior to the control group.

l      Dosage and Administration

Orally, 10-20ml/each time, 2-3 times/per day , or listen to your doctor's advice

l      Side effects

Sanyang kantai medicine is made from natural plants. It has been used to perform acute toxicity tests and long-term toxicity tests, and no toxicity and side effects have been found.

l      Precautions

If there is any sedimentation in this kind of herb, it will not affect the curative effect and quality. Before using it, please shake it first.

l      Contraindications

 Do not use this medicine if you have a cold.

l      Specifications 

10ml *10 pieces/case in 100ml/bottles.

l      Package   

PVC/PE composite membrane and light-resistant glass bottle for inner packing; cartons for the outer packing.

l      Shelf Life   18 months.

l      Approval Certificate No.   Z20025065

l      Manufacturer  

Beijing Zhenyouyuan Biological Medicine Manufacturing Co., Ltd. 

Yunnan Dianzhong Pharmaceutical Co., Ltd.

l      Storage    Sealed and kept in a cool, shaded area.

l      Telephone    0086-10-65532628   0086-871-8323649

l      Fax    0086-10-65532628  0086-871-8315080

l      E-mail    zyykj@vip.sina.com      zyykj@zyyok.com